Barrier & repair
PDRN
Also listed as polydeoxyribonucleotide, salmon DNA, sodium DNA and polynucleotides (related)
PDRN is a mix of DNA fragments, traditionally from salmon or trout, used in Korean clinics as an injectable 'skin booster' and now in serums and creams.
What it does
The short version.
In medicine and aesthetics, PDRN is mostly injected or used after procedures, where studies suggest it supports tissue repair and wound healing. In topical skincare the idea is the same, but delivery is the problem: PDRN molecules are large and negatively charged, which limits how far they penetrate, so newer formulas use shorter, processed fragments. Expect hydration and comfort from the formula as a whole; the strongest PDRN evidence is for injected use in healing skin, not for creams on aging skin.
Emerging evidence
A systematic review of randomized trials finds PDRN's effects clearest in tissue undergoing active repair, and most trials involve injections; topical evidence is limited to small and laboratory studies.
Reach for it for
Usually a good fit for
How to use it
Getting it right.
Apply serums or creams after cleansing and toning, once or twice daily, followed by moisturizer and daytime sunscreen.
Layering
Friends & frenemies.
Pairs well with
Before you start
Often derived from fish, so it isn't vegan; people with fish allergies should check with a doctor. Clinic injections are a medical procedure and should only be done by a licensed professional.
References
- 1Polynucleotides and Polydeoxyribonucleotides for Skin Rejuvenation, Postoperative Scar Prevention, and Wound Healing: A Systematic Review of Randomized Clinical Trials — PubMed Central
- 2Plasma-Engineered PDRN: Surface Charge Neutralization and Nanosizing Enhance Uptake and Regeneration Potential — PubMed Central
- 3Anti-Aging Efficacy of Low-Molecular-Weight Polydeoxyribonucleotide Derived from Paeonia lactiflora — PubMed Central
Educational, not medical advice. Ingredient guides summarise published research and expert guidance; formulas and concentrations differ between products.
No pdrn products reviewed yet.
We add products every week. The guide above still stands — and Beauty Match can find what suits you today.
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